|
Acute Promyelocytic Leukemia
|
0.700 |
FusionGene
|
disease |
ORPHANET |
"Characterization of acute promyelocytic leukemia cases lacking the classic t(15;17): results of the European Working Party. Groupe Français de Cytogénétique Hématologique, Groupe de Français d'Hematologie Cellulaire, UK Cancer Cytogenetics Group and BIOMED 1 European Community-Concerted Action ""Molecular Cytogenetic Diagnosis in Haematological Malignancies""."
|
10942371 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that PML/RARA-mediated downregulation of <i>Irf8</i> transcript levels contributes to the initiation of APL.
|
30266821 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Acute promyelocytic leukaemia (APL) driven by chimeric transcription factors encoding retinoic acid receptor alpha fusions is the paradigm of targeted cancer therapy, in which the application of all-trans retinoic acid (ATRA) treatments have markedly transformed this highly fatal cancer to a highly manageable disease.
|
25247321 |
2015 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Topoisomerase IIbeta negatively modulates retinoic acid receptor alpha function: a novel mechanism of retinoic acid resistance.
|
18212063 |
2008 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
From a retinoic acid (RA)-sensitive acute promyelocytic leukemia (APL) cell line, we derived an RA-resistant clone characterized by a block in transcription initiation, despite maintaining wild-type PML/RARA expression.
|
26997274 |
2016 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In the NB4 model of acute promyelocytic leukemia (APL), ATRA, 9-cis retinoic acid (9-cis RA), the pan-RAR and RARalpha-selective agonists, TTNPB and AM580, induce growth inhibition, granulocytic differentiation and apoptosis.
|
10800078 |
2000 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The RAR alpha gene fuses to variable partners (PML, PLZF, NPM, NuMA and STAT5B: X genes) leading to the expression of APL-specific fusion proteins with identical RAR alpha moieties.
|
16331271 |
2006 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Differentiated APL blasts sorted from uncoupled retinoid-treated mice retain PML/RARA expression and reinitiate APL in secondary transplants.
|
23509325 |
2013 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Six patients with acute promyelocytic leukaemia (APL) and t(15;17) were investigated by cytogenetics and by reverse transcriptase polymerase chain reaction (RT-PCR) for the fusion transcript PML-RARA.
|
8947582 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic leukemia zinc finger-retinoic acid receptor-alpha fusion protein.
|
8622986 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Arsenic trioxide, a drug for patients with acute promyelocytic leukemia, is found to target and degrade a class of proteins with high levels of cysteine residues and vicinal thiol groups, such as promyelocytic leukemia protein (PML) and PML-retinoic acid receptor α fusion protein.
|
21454520 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
By using a murine leukemic model carrying both promyelocytic leukemia zinc finger/retinoic acid receptor-α (PLZF/RARα) and RARα/PLZF fusion genes, we discovered that 8-chlorophenylthio adenosine-3', 5'-cyclic monophosphate (8-CPT-cAMP) enhances cellular differentiation and improves gene trans-activation by ATRA in leukemic blasts.
|
23382200 |
2013 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Previous studies indicated that in acute promyelocytic leukemia (APL), a subtype of acute myelogenous leukemia (AML) bearing the leukemia promoting PML/RARα fusion protein, let-7c expression seems to be controlled by the host gene promoter, in which canonical Retinoic Acid Responsive Elements (RAREs) are bound by PML/RARα in an all transretinoic acid (ATRA)-sensitive manner.
|
24637061 |
2014 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Predictive value of RT-PCR PML-RARA transcript monitoring for extramedullary relapse of acute promyelocytic leukemia in the pleura, heart and pericardium after allogeneic SCT.
|
18290568 |
2007 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
One form of APL is associated with the translocation t(11;17), which joins the promyelocytic leukemia zinc finger (PLZF) and retinoic acid receptor alpha (RARalpha) genes.
|
11719366 |
2001 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Reverse-transcription polymerase chain reaction (RT-PCR) amplification of PML-RARalpha messenger RNA can establish the diagnosis of APL, predict response to all-trans retinoic acid and arsenic trioxide, detect minimal residual disease, and predict relapse.
|
12895391 |
2003 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Of 84 cases (63%) that lacked monocytic differentiation ("myeloid AML"), 40 (48%) demonstrated an acute promyelocytic leukemia-like (APL-like) immunophenotype by flow cytometry, with absence of CD34 and HLA-DR and strong myeloperoxidase expression, in the absence of a PML-RARA translocation.
|
29274134 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
The t(15;17) translocation causes a disruption of the retinoic acid receptor alpha (RAR-alpha) and allows for the expression of the PML-RAR alpha fusion protein considered to be responsible for the differentiation block in acute promyelocytic leukemia (APL).
|
8788037 |
1996 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Identification of the STAT5B-RARα fusion transcript in an acute promyelocytic leukemia patient without FLT3, NPM1, c-Kit and C/EBPα mutation.
|
21447089 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
LHGDN |
Reduced PU.1 expression causes myeloid progenitor expansion and increased leukemia penetrance in mice expressing PML-RARalpha.
|
16113082 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Regulation of CYP26A1 expression by selective RAR and RXR agonists in human NB4 promyelocytic leukemia cells.
|
15896339 |
2005 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To identify these, we used a mouse model of APL, whereby PML-RARA expressed in myeloid cells leads to a myeloproliferative disease that ultimately evolves into APL.
|
21436584 |
2011 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Collectively, our data indicate that CDKN2D repression by PML/RARα disrupts both cell proliferation and differentiation in the pathogenesis of APL, and induced expression of CDKN2D by ATRA alleviates the disruption of both processes to ensure treatment efficiency.
|
25275592 |
2014 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Influence of bcr-3 PML-RARα transcript on outcome in Acute Promyelocytic Leukemia patients of Kashmir treated with all-trans retinoic acid and/or arsenic tri-oxide.
|
30803552 |
2019 |
|
Acute Promyelocytic Leukemia
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the bone marrow cells at diagnosis showed strong expression of BMP-2, -4, and -7, and their receptors RIA, RIB, and RII, parallel to the expression of promyelocytic leukemia/retinoic acid receptor alpha (PML/RARalpha) fusion gene transcripts.
|
12801531 |
2003 |